The Dutch, 27, suffered the injury during the arsenal win by 2-1 over Blackburn in the Premier League on August 28.
The Dutch football association had Forecast would be off to "at least a few weeks", however, the problem is worse than feared for the first time.
Van Persie missed five months last season after ankle ligament damage while in international law.
His latest injury rules him out of two first Champions League group stage games arsenal at home for Braga on September 15 and off Partizan Belgrade 13 days later.
It seems likely that he will miss at least five games of Premier League, including the North London Derby in Tottenham on September 21 and distance to leaders Chelsea on October 3.
The Dutch, however, will have to do without it to qualify for Euro 2012 against Moldova and Sweden next month, with Ruud van Nistelrooy Hamburg should continue to fill the violation in the cast.
Van Persie injury resulted in the former Manchester United and Real Madrid forward Van Nistelrooy invoked by the Netherlands for the first time in two years, as the 34-year-old came off the bench to score once in his country's opening group E qualifier on Friday – a 5-0 victory over San Marino.
After missing much of last season due to injury, Van Persie a constant as the Netherlands reached the final of World Cup this summer, but he had a frustrating start to the current national campaign.
Total fitness mismatch, he made only brief appearances in opening fixtures for arsenal against Liverpool and Blackpool before his first game of the campaign was interrupted by injury after 35 minutes on Saturday.
Marouane Chamakh, who led the line after replacing Van Persie on Saturday, is likely to continue to play as sola arsenal forward with Denmark international Nicklas Bendtner also available because of a groin injury.
However, there is better news for the Gunners Manager Arsene Wenger, the Middle Samir Nasri.
The French hurt his knee in the 1-1 League draw in Liverpool on August 15th. However, according to a statement on the site of Arsenal, Nasri "returns to training the next few days", after being initially anticipated to be discarded by a month.
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